DSGEr - Transcriptional Disruption Score for Gene Sets

Computes pathway-level transcriptional disruption scores from differential expression p-values using permutation tests with Generalized Pareto Distribution (GPD) tail extrapolation and false discovery rate (FDR) correction. Reference: Guo P, Li H (2026) DSGE: Disruption Score of Gene Expression for Gene-Set Enrichment Analysis. <https://github.com/LHJLab/DSGE>.